WHAT IT IS
Mass range refers to the span of m/z values that a mass spectrometer can measure. It is typically expressed as the minimum and maximum m/zm/zm/z values detectable by the instrument. The design and capabilities of the mass analyzer directly influence the achievable mass range.
IMPACT ON PERFORMANCE
Broad Applicability: Instruments with a wide mass range can analyze diverse sample types.
Molecular Coverage: A sufficient mass range ensures that all analytes of interest in a sample can be detected, improving the comprehensiveness of analysis.
Flexibility: Mass range determines the instrument's ability to adapt to different applications.
CHALLENGES AND LIMITATIONS
Resolution Trade-offs: Expanding the mass range may reduce resolution or sensitivity, especially at the extreme ends of the range, depending on the mass analyzer design.
Detector Limitations: Detectors may struggle to maintain accuracy across a very broad mass range, requiring advanced calibration and maintenance.
Instrument Complexity: Instruments designed for broad mass ranges often require sophisticated configurations, increasing cost and maintenance needs.